Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes (115.16)
| العنوان: | Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes (115.16) |
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| المؤلفون: | Kavitha Narayan, Katelyn Sylvia, Nidhi Malhotra, Catherine Yin, Gregory Martens, Therese Vallerskog, Hardy Kornfeld, Na Xiong, Nadia Cohen, Michael Brenner, Leslie Berg, Joonsoo Kang, The Immunological Genome Project Consortium |
| المصدر: | The Journal of Immunology. 188:115.16-115.16 |
| بيانات النشر: | The American Association of Immunologists, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Two distinct lineages of T cells, distinguished by expression of either an αβ or γδ T cell receptor (TCR), arise from a common progenitor in the thymus. The type of pathogen and the cytokine milieu directs effector differentiation of αβ T cells in the periphery through the induction of specific transcriptional networks. γδ T cell development is distinct from that of αβ T cells in its ordered rearrangement of TCR genes and the pairing of Vγ and Vδ chains to generate γδ T cell subsets that home to specific tissues. While γδ T cells have primarily been studied as one homogenous population, they can be functionally classified into effector subsets based on the production of signature cytokines, analogous to αβ T helper subsets. Unlike αβ T cells, γδ T cell effector function correlates with genomically encoded TCR chains, but the mechanism of γδ effector specification is unclear. In conjunction with the Immunological Genome Project Consortium, we performed a high resolution transcriptome analysis of all emergent γδ thymocyte subsets segregated based on TCRγ/δ chain usage and maturation state in the thymus. Our data indicate the existence of three separate subtypes of γδ T cells in the thymus. The profiles of the emergent immature γδ T cell subsets are already embedded with unique gene programs directing subset-specific effector function, indicating that γδ T cell effector function is molecularly programmed in the thymus prior to, or concurrent with, TCR expression. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::33f32a214ba15da624a1d67732649d54 https://doi.org/10.4049/jimmunol.188.supp.115.16 |
| رقم الأكسشن: | edsair.doi...........33f32a214ba15da624a1d67732649d54 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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