Discovery of Novel Small Molecule Growth Inhibitors to Manage Pseudomonas Leaf Spot Disease on Peppers (Capsicum sp.)
| العنوان: | Discovery of Novel Small Molecule Growth Inhibitors to Manage Pseudomonas Leaf Spot Disease on Peppers (Capsicum sp.) |
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| المؤلفون: | Sochina Ranjit, Loic Deblais, Francesca Rotondo, Brandon Shannon, Reed Johnson, Sally Ann Miller, Gireesh Rajashekara |
| المصدر: | Plant Disease. |
| بيانات النشر: | Scientific Societies, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Plant Science, Agronomy and Crop Science |
| الوصف: | Pseudomonas leaf spot (PLS) disease in peppers caused by Pseudomonas syringae pv. syringae (Pss), is an emerging seed-borne phytopathogen. Pss infection can severely reduce the marketable yield of peppers in favorable environmental conditions and cause significant economic losses. The intensive use of copper-sulfate and streptomycin-sulfate to control PLS and other bacterial diseases is associated with antimicrobial-resistant-Pss strains, making these control methods less effective. Hence, there is an urgent need to develop novel antimicrobials effective against Pss in peppers. Several studies, including those done in our laboratory, have shown that small molecule (SM) antimicrobials are ideal candidates as they can be effective against multi-drug resistant bacteria. Therefore, our study aims to identify novel SM growth inhibitors of Pss, assess their safety, and evaluate their efficacy on Pss-infected pepper seeds and seedlings. Using high throughput screening we identified 10 SMs (PC1 to PC10) that inhibited the growth of Pss strains at 200 µM or lower concentrations. These SMs were effective against both copper- and streptomycin-resistant as well as biofilm-embedded Pss. These SMs were effective against other plant pathogens (n=22) at low concentrations ( |
| تدمد: | 1943-7692 0191-2917 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::33fde2869040c9bb4bcacc3649d9665b https://doi.org/10.1094/pdis-12-22-2976-re |
| رقم الأكسشن: | edsair.doi...........33fde2869040c9bb4bcacc3649d9665b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19437692 01912917 |
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