Synthesis of 2β-Acyl-3β-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and Their Binding Affinities at Dopamine and Serotonin Transport Sites
| العنوان: | Synthesis of 2β-Acyl-3β-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and Their Binding Affinities at Dopamine and Serotonin Transport Sites |
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| المؤلفون: | Ren P, Hammond Ps, Elie Saikali, Childers, Kuhn La, T. Sexton, Gilliatt, Davies Hm |
| المصدر: | Journal of Medicinal Chemistry. 44:1509-1515 |
| بيانات النشر: | American Chemical Society (ACS), 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | biology, Chemistry, Stereochemistry, Dopamine Plasma Membrane Transport Proteins, Serotonin transport, Transporter, Tropane, chemistry.chemical_compound, Dopamine, Drug Discovery, Serotonin Plasma Membrane Transport Proteins, medicine, biology.protein, Molecular Medicine, Serotonin, Serotonin transporter, medicine.drug |
| الوصف: | A series of 3β-naphthyltropane derivatives were synthesized and found to show high affinity at both the dopamine and serotonin transporter sites, leading to some of the most potent inhibitors known based on the tropane structure. Comparative molecular field analysis (CoMFA) models were developed for both dopamine and serotonin transporter binding data. These models provide insights into those factors that influence binding at the two transporters. |
| تدمد: | 1520-4804 0022-2623 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::343b0f185d717c1b4c27a96e5eb72c04 https://doi.org/10.1021/jm000363+ |
| رقم الأكسشن: | edsair.doi...........343b0f185d717c1b4c27a96e5eb72c04 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15204804 00222623 |
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