Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: anticancer activity evaluation and mode of action study
| العنوان: | Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: anticancer activity evaluation and mode of action study |
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| المؤلفون: | Beatriz Zayas, Sanjay V. Malhotra, Vineet Kumar, Anuj Thakur, Christian E. Vélez Gerena, Sunny Manohar, Diwan S. Rawat |
| المصدر: | Med. Chem. Commun.. 5:576-586 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Pharmacology, Stereochemistry, Organic Chemistry, Pharmaceutical Science, Cancer, medicine.disease, Biochemistry, chemistry.chemical_compound, chemistry, Mechanism of action, Apoptosis, Drug Discovery, Curcumin, medicine, Molecular Medicine, medicine.symptom, Mode of action |
| الوصف: | A series of eighteen novel 3,5-bis(arylidiene)-4-piperidone based symmetrical monocarbonyl analogs of curcumin were synthesised and a subset was screened by National Cancer Institute (NCI), USA for their anticancer activity. Dose–response studies and the mechanism of action investigation suggest that most active compounds are apoptosis inducers. |
| تدمد: | 2040-2511 2040-2503 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::36052b57f6693a94ce4106aaec01cd45 https://doi.org/10.1039/c3md00399j |
| رقم الأكسشن: | edsair.doi...........36052b57f6693a94ce4106aaec01cd45 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20402511 20402503 |
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