Objective: We aimed to compare Tolterodine and Solifenacin in Urinary Incontinence patients and we also assessed all the associated side effects. Material and Methods: We carried out a comparative research at Obstetrics and Gynecology Department of Allied Hospital, Faisalabad from September 2016 to March 2017 on a total of 830 Urinary Incontinence patients. We carried out an assessment of every patient for the presence of possible side effect between Tolterodine and Solifenacin. Results: Women diagnosed with Urinary Incontinence were selected with a mean age of (57.34 ± 11.54) years. Research sample had a subdivision of Group – I and II. Group – I had all the patients who had Solifenacin Succinate (5mg) treatment; whereas, Tolterodine (4mg) treated cases were in Group – II. A total of 123 cases had Mouth Dryness (29.64%) were included in Group – I and 101 cases (24.34%) were included in Group – II (P 0.085). Whereas, 41 cases of constipation (9.88%) were included in Group – I and 21 cases of constipation (5.96%) were included in Group – II (P 0.000). Conclusion: Five milligrams of Solifenacin succinate were caused higher constipation occurrence than four milligrams of Tolterodine; whereas, dry mouth incidence was not significant but reported higher in the patients. Outcomes clearly reflect variation in the side effects between Solifenacin succinate and Tolterodine as observed in urinary incontinence patients. Keywords: Solifenacin, Anti Muscarinic, Overactive Bladder, Tolterodine, Constipation and Dry Mouth.
