Aneuploidy in pancreatic insulinomas does not predict malignancy
| العنوان: | Aneuploidy in pancreatic insulinomas does not predict malignancy |
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| المؤلفون: | George L. Nardi, Frederic I. Preffer, Thomas J. Flotte, Fiona Graeme-Cook, Debra A. Bell, Carolyn C. Compton, Cecile Pastel-Levy |
| المصدر: | Cancer. 66:2365-2368 |
| بيانات النشر: | Wiley, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Cancer Research, Pathology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Aneuploidy, Disease, Malignancy, medicine.disease, Flow cytometry, chemistry.chemical_compound, Oncology, DNA profiling, chemistry, medicine, Ploidy, business, DNA, DNA ploidy analysis |
| الوصف: | Nuclear deoxyribonucleic acid (DNA) ploidy studies with paraffin embedded archival material from 14 pancreatic insulinomas were performed by flow cytometry. Clinical follow-up (2 to 17 years; mean, 8 years) was obtained for all patients. Half of the tumors had a normal DNA histogram and half exhibited an abnormal DNA profile consistent with DNA aneuploidy. Six of the seven patients with aneuploid tumors are alive and disease free (2 to 5 years postresection), and one is alive with metastatic disease. Of the seven patients with tumors showing normal DNA profiles, five are alive and disease free, one is dead of disease, and one is alive with metastatic disease. These data suggest that DNA ploidy analysis is unlikely to provide useful prognostic information for patients with insulinomas. |
| تدمد: | 1097-0142 0008-543X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::37007544dfc91a187350204be47ba166 https://doi.org/10.1002/1097-0142(19901201)66:11<2365::aid-cncr2820661119>3.0.co;2-l |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........37007544dfc91a187350204be47ba166 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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