A carbapenem-focused antimicrobial stewardship programme implemented during the COVID-19 pandemic in a setting of high endemicity for multidrug-resistant Gram-negative bacteria
| العنوان: | A carbapenem-focused antimicrobial stewardship programme implemented during the COVID-19 pandemic in a setting of high endemicity for multidrug-resistant Gram-negative bacteria |
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| المؤلفون: | Nikolaos Spernovasilis, Evangelos I Kritsotakis, Anna Mathioudaki, Alexandra Vouidaski, Christos Spanias, Maria Petrodaskalaki, Petros Ioannou, Georgios Chamilos, Diamantis P Kofteridis |
| المصدر: | Journal of Antimicrobial Chemotherapy. 78:1000-1008 |
| بيانات النشر: | Oxford University Press (OUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Pharmacology, Microbiology (medical), Infectious Diseases, Pharmacology (medical) |
| الوصف: | Background Background Greece is among the countries characterized by high rates of antimicrobial resistance and high consumption of antibiotics, including carbapenems. Objectives To measure the impact of a carbapenem-focused antimicrobial stewardship programme (ASP) on the antibiotic consumption and patient outcomes in a Greek tertiary hospital during the COVID-19 pandemic. Methods A quasi-experimental, before–after study, comparing a 12 month pre-intervention period with a 12 month intervention period in which a carbapenem-focused ASP was implemented. Results A total of 1268 patients were enrolled. The proportion of admitted patients who received carbapenems decreased from 4.1% (842 of 20 629) to 2.3% (426 of 18 245) (−1.8%; P Conclusions Implementing and maintaining a carbapenem-focused ASP is feasible, effective and safe in settings with high rates of antimicrobial resistance, even during the COVID-19 pandemic. |
| تدمد: | 1460-2091 0305-7453 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::371dfcb6a10045d721fa31ef534f7f66 https://doi.org/10.1093/jac/dkad035 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........371dfcb6a10045d721fa31ef534f7f66 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602091 03057453 |
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