Neither glucagon-like peptide 1 receptors nor GDNF family receptor α-like neurons are required for aversive or anorectic response to deoxynivalenol (vomitoxin)
| العنوان: | Neither glucagon-like peptide 1 receptors nor GDNF family receptor α-like neurons are required for aversive or anorectic response to deoxynivalenol (vomitoxin) |
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| المؤلفون: | Anita R. Patel, Henriette Frikke-Schmidt, Paul V. Sabatini, Alan C. Rupp, Darleen A. Sandoval, Martin G. Myers, Randy J. Seeley |
| المصدر: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 324:R635-R644 |
| بيانات النشر: | American Physiological Society, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Physiology, Physiology (medical) |
| الوصف: | Deoxynivalenol (DON), a type B trichothecene mycotoxin contaminating grain, promotes nausea, emesis, and anorexia. With DON exposure, circulating levels of intestinally derived satiation hormones, including glucagon-like peptide 1 (GLP-1), are elevated. To directly test whether GLP-1 signaling mediates the effects of DON, we examined the response of GLP-1 or GLP-1R-deficient mice to DON injection. We found comparable anorectic and conditioned taste avoidance learning responses in GLP-1/GLP-1R-deficient mice compared with control littermates, suggesting that GLP-1 is not necessary for the effects of DON on food intake and visceral illness. We then used our previously published data from translating ribosome affinity purification with RNA sequencing (TRAP-seq) analysis of area postrema neurons that express the receptor for the circulating cytokine growth differentiation factor (GDF15), GDNF family receptor α-like (GFRAL). Interestingly, this analysis showed that a cell surface receptor for DON, a calcium-sensing receptor (CaSR), is heavily enriched in GFRAL neurons. Given that GDF15 potently reduces food intake and can cause visceral illness by signaling through GFRAL neurons, we hypothesized that DON may also signal by activating CaSR on GFRAL neurons. Indeed, circulating GDF15 levels are elevated after DON administration, but both GFRAL knockout and GFRAL neuron-ablated mice exhibited similar anorectic and conditioned taste avoidance responses compared with WT littermates. Thus, GLP-1 signaling and GFRAL signaling and neurons are not required for DON-induced visceral illness or anorexia. |
| تدمد: | 1522-1490 0363-6119 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::375e525da4f6d012f2c7a6aedb8f470b https://doi.org/10.1152/ajpregu.00189.2022 |
| رقم الأكسشن: | edsair.doi...........375e525da4f6d012f2c7a6aedb8f470b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221490 03636119 |
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