| الوصف: |
Introduction: Maturity-onset diabetes of the young (MODY) is a rare disease due to a single gene mutation that affects several family members in most cases. The Krüppel-like factor 11 (KLF11) gene mutation is associated with decreased insulin sensitivity to high glucose levels. KLF 11 has been implicated in the pathogenesis of MODY type 7 but given its low prevalence, prolonged subclinical period, and the emergence of new information, doubts are raised about its association. Methods: A literature search of the PubMed, Scopus, and EBSCO databases was performed. The terms “Diabetes Mellitus, Type 2/genetics”, “Mason-Type Diabetes,” “Maturity-Onset diabetes of the young,” “KLF11 protein, human”, and “Maturity-Onset Diabetes of the Young, Type 7” were used. ,” “Diagnosis,” The search selection was not standardized. Results: The KLF1 mutation is rare and represents Conclusion: MODY type 7 diabetes represents a rare form of monogenic diabetes with incomplete penetrance. Given its rarity, its association with impaired glucose metabolism has been questioned. Strict evaluation of glycemic control and the appearance of microvascular complications are key areas in the follow-up of patients diagnosed with MODY 7. More studies will be required to characterize the population with KLF11 mutation and clarify its correlation with MODY. |
