Clinical Evaluation of (4S)-4-(3-[18F]Fluoropropyl)-L-glutamate (18F-FSPG) for PET/CT Imaging in Patients with Newly Diagnosed and Recurrent Prostate Cancer
| العنوان: | Clinical Evaluation of (4S)-4-(3-[18F]Fluoropropyl)-L-glutamate (18F-FSPG) for PET/CT Imaging in Patients with Newly Diagnosed and Recurrent Prostate Cancer |
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| المؤلفون: | Yong Mee Cho, Meena Kumar, Dae Hyuk Moon, Sae Jung Na, Erik Mittra, Sonya Youngju Park, Sanjiv S. Gambhir, Andre Mueller, Santiago Bullich, Mathias Berndt, Mirwais Wardak, Norman Koglin, Andrew Stephens, Sun Young Chae, Camila Mosci, Hye Ok Kim, Hanjong Ahn |
| المصدر: | Clinical Cancer Research. 26:5380-5387 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Biodistribution, biology, business.industry, CD44, Cancer, medicine.disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Text mining, Oncology, 030220 oncology & carcinogenesis, biology.protein, Medicine, Immunohistochemistry, In patient, Histopathology, business, Nuclear medicine |
| الوصف: | Purpose: (4S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid (18F-FSPG) is a radiopharmaceutical for PET imaging of system xC− activity, which can be upregulated in prostate cancer. We present data on the first evaluation of patients with newly diagnosed or recurrent prostate cancer with this radiopharmaceutical. Experimental Design: Ten patients with primary and 10 patients with recurrent prostate cancer were enrolled in this prospective multicenter study. After injection of 300 MBq of 18F-FSPG, three whole-body PET/CT scans were obtained. Visual analysis was compared with step-section histopathology when available as well as other imaging studies and clinical outcomes. Metabolic parameters were measured semiquantitatively. Expression levels of xCT and CD44 were evaluated by IHC for patients with available tissue samples. Results: 18F-FSPG PET showed high tumor-to-background ratios with a relatively high tumor detection rate on a per-patient (89%) and per-lobe (87%) basis. The sensitivity was slightly higher with imaging at 105 minutes in comparison with 60 minutes. The maximum standardized uptake values (SUVmax) for cancer was significantly higher than both normal (P < 0.005) and benign pathology (P = 0.011), while there was no significant difference between normal and benign pathology (P = 0.120). In the setting of recurrence, agreement with standard imaging was demonstrated in 7 of 9 patients (78%) and 13 of 18 lesions (72%), and revealed true local recurrence in a discordant case. 18F-FSPG accumulation showed moderate correlation with CD44 expression. Conclusions: 18F-FSPG is a promising tumor imaging agent for PET that seems to have favorable biodistribution and high cancer detection rate in patients with prostate cancer. Further studies are warranted to determine the diagnostic value for both initial staging and recurrence, and how it compares with other investigational radiotracers and conventional imaging modalities. |
| تدمد: | 1557-3265 1078-0432 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::3ae75aa90ae20a463a89e81982db269f https://doi.org/10.1158/1078-0432.ccr-20-0644 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........3ae75aa90ae20a463a89e81982db269f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15573265 10780432 |
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