This paper is focused on analysing the difference in distribution, composition and abundance of benthic invertebrates' populations of the rocky coast of Sazan Island (south western Albania), between its eastern and western sides. This study was carried out during 2012-2014, sampling in shallow water. A total of 56 species of benthic macroinvertebrates were recorded. Species composition and their abundance were compared between the four sampling sites and between the two sampling seasons, spring and autumn. Degree of coast exposure and level of environmental impacts seem to be the main factors regarding the difference in species composition and quantitative characteristics of macrozoobenthic community between the eastern and western coasts of the island.