Bottom-up Structural Design of Crystalline Drug-Excipient Composite Microparticles via Microfluidic Droplet-based Processing
| العنوان: | Bottom-up Structural Design of Crystalline Drug-Excipient Composite Microparticles via Microfluidic Droplet-based Processing |
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| المؤلفون: | Ambika Somasundar, Marc Garland, Denise Z. L. Ng, Eunice W. Q. Yeap, Andrew J. Acevedo, Ammu Prhashanna, Fatma Salahioglu, Saif A. Khan, Qisong Xu |
| المصدر: | Crystal Growth & Design. 17:3030-3039 |
| بيانات النشر: | American Chemical Society (ACS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Materials science, Microfluidics, Composite number, Excipient, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, law.invention, chemistry.chemical_compound, Ethyl cellulose, law, medicine, General Materials Science, Crystallization, chemistry.chemical_classification, General Chemistry, Polymer, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Solvent, chemistry, Particle, 0210 nano-technology, medicine.drug |
| الوصف: | We present a simple, bottom up method for the structural design of solid microparticles containing crystalline drug and excipient using microfluidic droplet-based processing. In a model system comprising 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY) as the drug and ethyl cellulose (EC) as the excipient, we demonstrate a diversity of particle structures, with exquisite control over the structural outcome at the single-particle level. Within microfluidic droplets containing drug and excipient, tuning droplet composition and solvent removal rates allows us to controllably access structural diversity via an interplay of three physical processes (liquid–liquid phase separation, drug crystallization, and polymer vitrification) occurring during solvent removal. Specifically, we demonstrate two levels of structural control—a coarse “macro” particle structure and a finer “micro” structure. Further, we elucidate the key mechanistic elements responsible for the observed structural diversity using a... |
| تدمد: | 1528-7505 1528-7483 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::3bb2100c5ab0ee3028da3f1fd63a5f2a https://doi.org/10.1021/acs.cgd.6b01701 |
| رقم الأكسشن: | edsair.doi...........3bb2100c5ab0ee3028da3f1fd63a5f2a |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15287505 15287483 |
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