Coralline lethal orange disease (CLOD) is a bacterial disease of reef-building crustose coralline algae that has been found in the Indo-Pacific, Red Sea, and Indian Ocean. It has been reported from a few areas within the Caribbean, but little is known about CCA diseases in this region. Here, we report the first observations of what looks like typical CLOD signs at four out of nine sites surveyed at Carrie Bow Cay, Belize.