Case series of dabrafenib-trametinib-induced pyrexia successfully treated with colchicine
| العنوان: | Case series of dabrafenib-trametinib-induced pyrexia successfully treated with colchicine |
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| المؤلفون: | Yiyi Yan, Lisa A. Kottschade, Roxana S. Dronca, Svetomir N. Markovic, Charles L. Loprinzi, Jessica Brandt, Axel Grothey, Robert R. McWilliams, Jesus Vera, Matthew S. Block, Jonas Paludo |
| المصدر: | Supportive Care in Cancer. 27:3869-3875 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | MAPK/ERK pathway, Trametinib, Kinase, business.industry, Familial Mediterranean fever, Dabrafenib, Pharmacology, medicine.disease, Rash, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Oncology, chemistry, 030220 oncology & carcinogenesis, medicine, Colchicine, 030212 general & internal medicine, medicine.symptom, Adverse effect, business, medicine.drug |
| الوصف: | The most common adverse event (AE) of dabrafenib and trametinib (DT) is pyrexia, which has been reported to occur in up to 71% of patients. Pyrexia resulted in therapy discontinuation in up to 26% of patients that otherwise were benefiting from the treatment. Little is known about the pathogenesis and optimal management of this common AE. We hypothesized that the etiology of pyrexia in patients treated with DT could be extrapolated from DT-related cutaneous adverse effects in which a paradoxical MAPK pathway activation has been identified. Based on preliminary data by our group suggesting an upregulation of the mitogen-activated protein kinases (MAPKs) in human lymphocytes exposed to dabrafenib and trametinib, specifically elevated expression of phosphorylated JNK (p-JNK), p38 MAPK (p-p38 MAPK), and ERK5 (p-ERK5), we hypothesized that the mechanism of MAPK pathway activation with DT therapy is similar to that reported in patients with familial Mediterranean fever (FMF), a rare, inherited condition characterized by episodes of fever and rash that responds exceedingly well to colchicine-based therapy in which the MAPK pathway is hyper-activated. Based on this association, our group explored the use of oral colchicine for the treatment of DT-associated pyrexia in five patients with metastatic melanoma. |
| تدمد: | 1433-7339 0941-4355 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::3d26ae3a68a2e65813a4e04c5dba76ad https://doi.org/10.1007/s00520-019-4654-2 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........3d26ae3a68a2e65813a4e04c5dba76ad |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14337339 09414355 |
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