Chemotherapy Effects on Natural Killer Cells in Children with Acute Lymphoblastic Leukemia
| العنوان: | Chemotherapy Effects on Natural Killer Cells in Children with Acute Lymphoblastic Leukemia |
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| المؤلفون: | Beyza Cetin, Tuğçe Aksu Uzunhan, Günnur Deniz, Sabriye Karadenizli, Serap Erdem Kuruca, Nilgun Akdeniz, Omer Devecioglu, Zeynep Karakas |
| المصدر: | Blood. 116:4326-4326 |
| بيانات النشر: | American Society of Hematology, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, Immunology, Cancer, Cell Biology, Hematology, medicine.disease, Biochemistry, Chemotherapy regimen, Radiation therapy, Immune system, Cytokine, Maintenance therapy, Interleukin 15, Internal medicine, Medicine, business |
| الوصف: | Abstract 4326 Intensive treatment of acute lymphoblastic leukemia in children has brought an increase of total remissions but also an increase of various complications resulting from toxicity of the treatment itself. One of the side effects of the use of cytostatics is their suppressive effect on the immune system. As an important element of the immune system, NK (Natural Killer) cells have critical roles in many different functions such as infection control, cancer surveillance, fetal implantation and cytokine production that will be affected by the immune suppresion. Dysfunctions of the NK cells by treatment are both of quantitative and qualitative nature. Our aim with this study is to analyze qualitative and quantitative chemotherapy induced changes on NK cells in children with acute lymphoblastic leukemia. Thirty three children aged between 2 and 19 years were included in the patient group. Their immunphenotypes, risk groups, prophylactic cranial radiation status and clinical characteristics were recorded. According to ALL BFM 2000 protocol, patients were classified into three groups: group 1 (patients who finished protocol M), group 2 (patients still on maintenance chemotherapy) and group 3 (patients who finished treatment). Control group (group 4) consisted of eleven healthy children aged between 2 and 13 years. NK cytotoxicity test, flow cytometric analysis of NK subgroups, cytokine analysis were performed in blood samples taken with informed consent from parents of both patients and controls. Clinical characteristics of the patients were evaluated with these results. Analysis was performed with “one way ANOVA” statistical test using SPSS 14.0. In 1:1 E:T ratio, group 2's NK cytotoxicity was significantly higher than any other group (p NK cells and subgroups in quantity seem to have decreased by the maintenance chemotherapy but not their functions. Group 2's (patients on maintenance therapy) higher NK cytotoxicity value may be due to low dose radiation's augmentation effect on NK cell functions as group 2 mostly consists of patients treated with prophylactic cranial radiation. A better understanding of NK cells changed by chemotherapy and radiotherapy will give us the opportunity of developing treatment that enhance their functions and so will contribute to the life quality of children with acute lymphoblastic leukemia (This project is sponsored by Istanbul University Research Fund, project number: T-889/02062006). Disclosures: Aksu Uzunhan: Istanbul University Istanbul Medical Faculty: Employment; Istanbul University Research Fund: Research Funding. |
| تدمد: | 1528-0020 0006-4971 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::3d64a5449b6d2cff448851c6ef042365 https://doi.org/10.1182/blood.v116.21.4326.4326 |
| رقم الأكسشن: | edsair.doi...........3d64a5449b6d2cff448851c6ef042365 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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