Neuro-psychiatrische Symptome bei Vitamin-B12-Mangel und Mikrokarzinoidose: Komplikationen einer chronischen atrophischen Gastritis
| العنوان: | Neuro-psychiatrische Symptome bei Vitamin-B12-Mangel und Mikrokarzinoidose: Komplikationen einer chronischen atrophischen Gastritis |
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| المؤلفون: | K.-M. Müller, L. M. Ossege, J.-P. Malin, T. Pohle, B. May |
| المصدر: | DMW - Deutsche Medizinische Wochenschrift. 121:758-762 |
| بيانات النشر: | Georg Thieme Verlag KG, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.diagnostic_test, biology, Atrophic gastritis, business.industry, Chromogranin A, Neurological examination, General Medicine, medicine.disease, Gastroenterology, Resorption, medicine.anatomical_structure, Internal medicine, medicine, biology.protein, Gastric mucosa, Vitamin B12, Gastritis, medicine.symptom, business, Mean corpuscular volume |
| الوصف: | HISTORY AND FINDINGS A 69-year-old woman reported marked restriction of voluntary movements of the hands in the preceding 6 months. She had also experienced loss of motivation, memory and concentration. Her skin was pale yellow, and scratches on her skin indicated marked pruritus. INVESTIGATIONS Neurological examination revealed decreased vibratory sense in both legs. Haemoglobin concentration was 8.3 g/dl, mean corpuscular volume 114 fl, vitamin B12 level < 100 ng/l, folic acid level normal. Antibody titre against parietal cells was increased, vitamin B12 resorption diminished. Gastroscopy revealed small raised lesions, made up of hyperplastic cells which stained with chromogranin, indicating a diagnosis of microcarcinoid of the gastric mucosa. TREATMENT AND COURSE On administration of cobalamine (1,000 micrograms i.m. daily for 2 weeks, twice weekly for 6 weeks, then once per week for the last 7 months) the blood picture returned to normal, but the microcarcinoids, the psychological symptoms and the apraxia of the hands were unchanged. |
| تدمد: | 1439-4413 0012-0472 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::3d93ab19ec1febf042c2bd0fa5375c0d https://doi.org/10.1055/s-2007-1024559 |
| رقم الأكسشن: | edsair.doi...........3d93ab19ec1febf042c2bd0fa5375c0d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14394413 00120472 |
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