ChemInform Abstract: Synthesis and Pharmacology of New Enantiopure Δ3-4-Arylkainoids
| العنوان: | ChemInform Abstract: Synthesis and Pharmacology of New Enantiopure Δ3-4-Arylkainoids |
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| المؤلفون: | Patrice Gill, Kenneth Curry, William D. Lubell, Monique Chan, Dany Rondeau |
| المصدر: | ChemInform. 31 |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Enantiopure drug, Chemistry, Stereochemistry, Antagonist, NMDA receptor, General Medicine, Receptor, Affinities |
| الوصف: | Seven delta(3)-4-arylkainoids possessing various 4-position aromatic and heteroaromatic groups were synthesized and their apparent affinities were measured in order to explore the influences of 4-position electron density and stereochemistry on receptor affinity and specificity. Kainoids 1a-f were shown to be selective agonists at the NMDA receptor and the electron rich furanyl and thienyl analogues exhibited the highest affinities. Naphthylkainoid 1g proved to be a nonselective antagonist at the iGluRs. |
| تدمد: | 1522-2667 0931-7597 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::3e8ca650b3843cbdfb2c2d0111d17cda https://doi.org/10.1002/chin.200029162 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........3e8ca650b3843cbdfb2c2d0111d17cda |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15222667 09317597 |
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