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TRPV4 Enhances Cardiomyocyte Calcium Transients and Cardiac Contractility Following Hypoosmotic Stress and Ischemia-Reperfusion

التفاصيل البيبلوغرافية
العنوان: TRPV4 Enhances Cardiomyocyte Calcium Transients and Cardiac Contractility Following Hypoosmotic Stress and Ischemia-Reperfusion
المؤلفون: Deborah Peana, Timothy L. Domeier, John L. Jones, Michelle D. Lambert
المصدر: Biophysical Journal. 112:95a-96a
بيانات النشر: Elsevier BV, 2017.
سنة النشر: 2017
مصطلحات موضوعية: 0301 basic medicine, TRPV4, Calcium metabolism, Osmole, medicine.medical_specialty, business.industry, Biophysics, Ischemia, chemistry.chemical_element, 030204 cardiovascular system & hematology, Calcium, medicine.disease, Contractility, 03 medical and health sciences, Transient receptor potential channel, 030104 developmental biology, 0302 clinical medicine, Endocrinology, chemistry, Internal medicine, medicine, business, Reperfusion injury
الوصف: The Transient Receptor Potential (TRP) ion channel family plays an important role in cardiomyocyte calcium homeostasis, particularly in diseased states. Here, we test the hypothesis that the osmotically-activated TRP Vanilloid 4 (TRPV4) channel enhances cardiomyocyte calcium transients in the aged heart following hypoosmotic stress. Expression of TRPV4 was low in cardiomyocytes of Young (3-6 month) mice, but significantly increased in cardiomyocytes of Aged (24-26 month) mice. In cardiomyocytes of Aged, hypoosmotic stress (250 mOsm) induced an increase in calcium transient amplitude (F/F0:3.6±0.1 hypoosmotic versus 2.9±0.2 isosmotic, P
تدمد: 0006-3495
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3eeb3332cee59ad44bfb793ef5669a04
https://doi.org/10.1016/j.bpj.2016.11.556
حقوق: OPEN
رقم الأكسشن: edsair.doi...........3eeb3332cee59ad44bfb793ef5669a04
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00063495