Impacts of pregnancy and menopause on COVID-19 severity: A systematic review and meta-analysis of 4.6 million women
| العنوان: | Impacts of pregnancy and menopause on COVID-19 severity: A systematic review and meta-analysis of 4.6 million women |
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| المؤلفون: | Yang Liu, Hang Li, Yuanyuan Peng, Liuming Gao, Chunmei Liu, Baozhu Wei, Zhi Luo |
| المصدر: | QJM: An International Journal of Medicine. |
| بيانات النشر: | Oxford University Press (OUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | General Medicine |
| الوصف: | Background COVID-19 pandemic is still a public health emergency of international concern. However, whether pregnancy and menopause impact the severity of COVID-19 remain unclear. Aim This study is performed to investigate the truth. Design Study appraisal and Synthesis follows PRISMA guideline. Meta-analysis is performed in random-effects model. Methods PubMed, Embase, Cochrane database, Central, CINAHL, ClinicalTrials.gov, WHO COVID-19 database, and WHO-ICTRP are searched until March 28 2023. Results In total, 57 studies (4,640,275 COVID-19 women) were analyzed. Pregnant women were at a lower risk of severe COVID-19, intensive care unit (ICU) admission and disease mortality compared to those nonpregnant women with comparable comorbidities. In contrast, pregnant women with more prepregnancy comorbidities were at a higher risk of severe COVID-19, ICU admission and invasive mechanical ventilation (IMV). In addition, pregnant women with pregnancy complications had a significantly increased risk of severe COVID-19 and ICU admission. Menopause increased COVID-19 severity, IMV requirement and disease mortality. Hormone replacement therapy (HRT) inhibited COVID-19 severity in postmenopausal women. Premenopausal and postmenopausal women had a lower chance of severe illness than age-matched men. The impact of pregnancy on COVID-19 severity was significant in Americans and Caucasians, while the effect of menopause on COVID-19 severity was only significant in Chinese. Conclusions Pregnancy and menopause are protective and risk factors for severe COVID-19, respectively. The protective role of pregnancy on COVID-19 is minimal and could be counteracted or masked by prepregnancy or pregnancy comorbidities. The administration of estrogen and progesterone may prevent severe COVID-19. |
| تدمد: | 1460-2393 1460-2725 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::3f18fd045756183247a2fe3b8b00c451 https://doi.org/10.1093/qjmed/hcad106 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........3f18fd045756183247a2fe3b8b00c451 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602393 14602725 |
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