Data from Genetic Alterations in the Tyrosine Kinase Transcriptome of Human Cancer Cell Lines

التفاصيل البيبلوغرافية
العنوان: Data from Genetic Alterations in the Tyrosine Kinase Transcriptome of Human Cancer Cell Lines
المؤلفون: Axel Ullrich, Byrappa Venkatesh, Sydney Brenner, Alice Tay, Stephan Peter, Stefano Iacobelli, Heinz Hoefler, Silvia Gaertner, Christian Mann, Martin Bezler, Tze Chuen Lee, Kaitian Peng, Han Kiat Ho, Ming Luo, Huimin Ong, Shu Jing Lim, Sharon Pok, Winnie Wong, Priscilla Foo, Hooi Linn Loo, Liang Seah Tay, Tatjana Knyazeva, Pjotr Knyazev, Katja Specht, Chee-Hong Wong, Stefan Hart, Sylvia Streit, Jens E. Ruhe
بيانات النشر: American Association for Cancer Research (AACR), 2023.
سنة النشر: 2023
الوصف: Protein tyrosine kinases (PTKs) play a critical role in the manifestation of cancer cell properties, and respective signaling mechanisms have been studied extensively on immortalized tumor cells. To characterize and analyze commonly used cancer cell lines with regard to variations in the primary structure of all expressed PTKs, we conducted a cDNA-based sequence analysis of the entire tyrosine kinase transcriptome of 254 established tumor cell lines. The profiles of cell line intrinsic PTK transcript alterations and the evaluation of 155 identified polymorphisms and 234 somatic mutations are made available in a database designated “Tykiva” (tyrosine kinome variant). Tissue distribution analysis and/or the localization within defined protein domains indicate functional relevance of several genetic alterations. The cysteine replacement of the highly conserved Y367 residue in fibroblast growth factor receptor 4 or the Q26X nonsense mutation in the tumor-suppressor kinase CSK are examples, and may contribute to cell line–specific signaling characteristics and tumor progression. Moreover, known variants, such as epidermal growth factor receptor G719S, that were shown to mediate anticancer drug sensitivity could be detected in other than the previously reported tumor types. Our data therefore provide extensive system information for the design and interpretation of cell line–based cancer research, and may stimulate further investigations into broader clinical applications of current cancer therapeutics. [Cancer Res 2007;67(23):11368–76]
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3f55dc700a793a59ab479a6d94797ad7
https://doi.org/10.1158/0008-5472.c.6496820
حقوق: OPEN
رقم الأكسشن: edsair.doi...........3f55dc700a793a59ab479a6d94797ad7
قاعدة البيانات: OpenAIRE