The Role of Coding and Regulatory RNAs during Acute Stress
| العنوان: | The Role of Coding and Regulatory RNAs during Acute Stress |
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| المؤلفون: | Ivan B. Filippenkov, L. V. Dergunova |
| المصدر: | Molecular Genetics, Microbiology and Virology. 35:129-133 |
| بيانات النشر: | Allerton Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0303 health sciences, 030306 microbiology, Coding (therapy), RNA, Cognition, Biology, Microbiology, Transcriptome, 03 medical and health sciences, Infectious Diseases, Virology, microRNA, Genetics, Stress conditions, Acute stress, Molecular Biology, Gene, Neuroscience, 030304 developmental biology |
| الوصف: | In the modern world, various forms of stressful conditions are an important problem for human health. The prolonged stress experienced by residents of large cities can lead to a decrease in cognitive functions and cause the development of anxiety disorders, depressive states, and more serious diseases. Studying the effect of stress and its consequences on the human body, as well as the development of antistress drugs, is an important task for modern science. The changes in the functioning of genes are the molecular genetic factors of stress manifestations; however, the mechanisms by which stress affects the functioning of genes are not fully understood. Analysis of the transcriptome underlies the study of gene functioning and is one of the most effective approaches to studying the mechanisms that determine the development of stress conditions and ways to achieve antistress effects of drugs. It has now been established that, in response to pathological effects, not only information RNAs (mRNAs) are involved, but also various types of noncoding RNAs, in particular, microRNAs and long noncoding RNAs (lncRNAs). Recently, the idea that lncRNAs can interact with microRNAs and inhibit their activity is actively being developed. Such functions are attributed to a new and actively studied type of RNA of circular nature (circRNAs). Recently, it has become apparent that the analysis of “noncoding RNA–mRNA” regulatory interactions is an important component part of the detailed study of the mechanisms of pathogenesis and stress-induced disorders. This review presents the latest data on the role of mRNAs and noncoding RNAs in acute stress, as well as under the action of antistress drugs. |
| تدمد: | 1934-841X 0891-4168 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::40036a0a0657c3ea92a5ab3ddcbeffb4 https://doi.org/10.3103/s0891416820030027 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........40036a0a0657c3ea92a5ab3ddcbeffb4 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1934841X 08914168 |
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