Lymphoid tissue is a microenvironment composed of B-, T-, and NK-lymphocytes in different maturation and differentiation stages, plasma cells, macrophages, dendritic cells, reticular cells, and granulocytes. For the diagnosis of lymphoma, all these components must be considered. For initial diagnosis, screening markers can be helpful. Further specific markers must be used for the precise diagnosis. Markers listed in different parts of this chapter are essentially used for orientation. The final diagnosis must be done according to the histomorphology, immunophenotype (immunohistochemistry and flow cytometry), and genetic analysis. The 2016 revision of the World Health Organization classification of lymphoid neoplasms was considered in this chapter.
