The effects of a grape seed extract on ligature induced – periodontitis in rats – an experimental study
| العنوان: | The effects of a grape seed extract on ligature induced – periodontitis in rats – an experimental study |
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| المؤلفون: | Cornel Catoi, Tudor Dimitriu, Soimita Suciu, Grigore Baciut, Gabriel Armencea, Zsofia Daradics, A. Cîmpean, Mihaela Baciut |
| المصدر: | Romanian Biotechnological Letters. 26:2347-2354 |
| بيانات النشر: | Digital ProScholar Media, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Periodontitis, food.ingredient, Traditional medicine, medicine.medical_treatment, food and beverages, Biology, medicine.disease, Applied Microbiology and Biotechnology, food, Grape seed extract, Genetics, medicine, Ligature, Agronomy and Crop Science, Biotechnology |
| الوصف: | The objective of this study was to evaluate the effects of administering a grape seed extract, rich in polyphenols in an experimental model of ligature induced periodontitis in rats. Methods: 30 male Wistar rats were divided into Control group, Ligature group and Grape seed extract (GSE) group. Periodontitis was induced by placing a wire ligature around the first mandibular molar for 4 weeks. The animals in the GSE group were administered grape seed extract by gavage. In days 1, 7 and 28 blood samples were taken and in day 28 the hemimandibles were harvested and sent for histological examination. Reduced glutathione (GSH) and malondialdehyde (MDA) were determined in serum and in gingival tissue. Results: Significantly higher values of MDA were found in serum and periodontium in the Ligature group in comparison to the GSE group. GSE administration resulted in an increase of GSH plasma concentration in the GSE group as compared to the Control and Ligature groups. In the GSE group inflammation and bone involvement were less marked than in the Ligature group. Conclusions: The grape seed extract proved protective anti-inflammatory and antioxidant effects in a ligature-induced experimental model of periodontitis in rats and also improved the histological status of gingival tissue and bone. |
| تدمد: | 2248-3942 1224-5984 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::410ffa5cb52772946a3be30590f83ca6 https://doi.org/10.25083/rbl/26.1/2347.2354 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........410ffa5cb52772946a3be30590f83ca6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22483942 12245984 |
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