Correlation of margin status and extraprostatic extension with progression of prostate carcinoma
| العنوان: | Correlation of margin status and extraprostatic extension with progression of prostate carcinoma |
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| المؤلفون: | Jeff Slezak, Michael F. Darson, Liang Cheng, Erik J. Bergstralh, Robert P. Myers, David G. Bostwick |
| المصدر: | Cancer. 86:1775-1782 |
| بيانات النشر: | Wiley, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Gynecology, Cancer Research, medicine.medical_specialty, Surgical margin, Univariate analysis, Prostatectomy, business.industry, medicine.medical_treatment, Urology, Cancer, medicine.disease, Oncology, medicine, Adjuvant therapy, Carcinoma, Progression-free survival, Positive Surgical Margin, business |
| الوصف: | RESULTS. The overall margin positivity rate was 29%. Seventy-two patients (19%) had only positive surgical margins without evidence of EPE (“surgical incision”), 53 (14%) had only EPE, 37 (10%) had both, and 215 (57%) had neither. Positive margins were correlated with the finding of EPE (P 5 0.003). Progression free survival rates at 5 and 10 years were 88% and 67%, respectively. In univariate analysis, preoperative PSA concentration, positive surgical margins, Gleason grade, cancer volume, and DNA ploidy were significant in predicting progression (P values, ,0.001, ,0.001, 0.01, 0.007, and ,0.001, respectively). In multivariate analysis, margin status and DNA ploidy were independent predictors of progression (relative risk for margin status, 1.9; 95% confidence interval [CI], 1.1‐3.4; P 5 0.03; relative risk for DNA ploidy, 5.1; 95% CI, 2.4 ‐10.9; P , 0.001). Among patients with positive margins, 5-year progression free survival was 78% for those with negative EPE and 55% for those with positive EPE. CONCLUSIONS. Surgical margin status and DNA ploidy were independent predictors of progression after radical prostatectomy. To improve cancer control, adjuvant therapy may be considered for patients with positive surgical margins or nondiploid cancer. Cancer 1999;86:1775‐ 82. © 1999 American Cancer Society. |
| تدمد: | 1097-0142 0008-543X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::4185a29ccc8956f1d35929098fc2beb7 https://doi.org/10.1002/(sici)1097-0142(19991101)86:9<1775::aid-cncr20>3.0.co;2-l |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........4185a29ccc8956f1d35929098fc2beb7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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