Antidepressants use is associated with overall survival improvement of patients with gastric cancer after surgery and adjuvant chemotherapy in Taiwan
| العنوان: | Antidepressants use is associated with overall survival improvement of patients with gastric cancer after surgery and adjuvant chemotherapy in Taiwan |
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| المؤلفون: | Yao-Hsu Yang, Yi-Chia Shen, Vincent Chin-Hung Chen, Pei-Rung Yang, Mong Liang Lu, Wei-Tai Shih, Ko-Jung Chen |
| المصدر: | Medicine. 100:e27031 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, business.industry, Proportional hazards model, Confounding, Hazard ratio, General Medicine, medicine.disease, Comorbidity, Confidence interval, Surgery, Defined daily dose, Medicine, Young adult, business, Cohort study |
| الوصف: | To determine whether exposure to antidepressants (ATDs) results in improved overall survival (OS) of patients with gastric cancer (GC) after surgery, we conducted a large cohort study and considered confounding factors that might affect the research outcomes.Patients who received a new diagnosis of GC and received surgery and chemotherapy between 1999 and 2008 were recruited and were classified into different groups based on the ATD level used. The association between the OS of patients with GC after surgery with different levels of ATD use, and the hazard ratio with comorbidities at different ATD use levels were compared.According to Kaplan-Meier method, the more of an ATD was taken, the longer the OS and a dose-dependent relationship was discovered in the OS curve; the adjusted HRs were 0.76 (95% confidence interval [CI] = 0.68-0.84) and 0.48 (95% CI = 0.41-0.57) for ATD users taking a cumulative defined daily dose (cDDD) of 28-167 and ≧168, respectively. Sensitivity analyzes were performed to investigate the effect of various comorbidities on OS with different degrees of ATD use and the results remained consistent among the varying models. Additionally, the effect of ATD use still exhibited a dose-dependent relationship in distinct stratifications for sex and age.The OS for patients with GC after surgery and chemotherapy improved with ATD use, and a dose-dependent relationship was discovered in this study. Further studies on the association between OS of GC and ATD use are required. |
| تدمد: | 1536-5964 0025-7974 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::430083a49a6ec7f61028f19329d70826 https://doi.org/10.1097/md.0000000000027031 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........430083a49a6ec7f61028f19329d70826 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 00257974 |
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