Towards epigenetic regulation of triple-negative breast cancer via ligand-mediated nanoparticles
| العنوان: | Towards epigenetic regulation of triple-negative breast cancer via ligand-mediated nanoparticles |
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| المؤلفون: | Guilherme F Picheth, Gabriela C Cardoso, Michelle B Collini, João OC Filizzola, Leonardo B Colauto, Giovana G Nunes, Cleverton L Pirich, Thiago Alessandre da Silva, Flávia LD Pontes, Ingrid F Zattoni, Edneia ASR Cavalieri, Giseli Klassen |
| المصدر: | Nanomedicine. 18:541-554 |
| بيانات النشر: | Future Medicine Ltd, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biomedical Engineering, Medicine (miscellaneous), General Materials Science, Bioengineering, Development |
| الوصف: | Aims: Develop and analyze triple-negative breast cancer targeted nanoparticles loaded with the demethylating agent decitabine. Materials & methods: The polymers were synthesized by ring-opening polymerization of D,L-lactide and formulated into nanoparticles via emulsion-evaporation method. The nanoparticles were characterized by physicochemical analysis as well as in vitro using breast cancer cell lineages. Results & conclusion: The targeted nanoparticles exhibited a hydrodynamic diameter of 75 ± 12 nm, zeta potential -6.3 ± 0.2 mV and spherical morphology, and displayed greater in vitro accumulation into MDA-MB-231 (triple-negative breast cancer cell-line) compared with MCF7 and HB4A cell lineages as verified by fluorescence confocal microscopy and significant demethylating effects via ADAM33 screening by PCR. |
| تدمد: | 1748-6963 1743-5889 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::433201f4f234e658f0f97363d63ba1b5 https://doi.org/10.2217/nnm-2023-0006 |
| رقم الأكسشن: | edsair.doi...........433201f4f234e658f0f97363d63ba1b5 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17486963 17435889 |
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