Efficacy and Tolerability of Travoprost 0.004%/Timolol 0.5%Fixed-Dose Combination for the Treatment of Primary Open-Angle Glaucoma or Ocular Hypertension Inadequately Controlled with Beta-Blocker Monotherapy
| العنوان: | Efficacy and Tolerability of Travoprost 0.004%/Timolol 0.5%Fixed-Dose Combination for the Treatment of Primary Open-Angle Glaucoma or Ocular Hypertension Inadequately Controlled with Beta-Blocker Monotherapy |
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| المؤلفون: | Ki Ho Park, Jose A Paczka, Douglas A. Hubatsch, Timothy V. Roberts, Simon Fabian Lerner, Valeriy Erichev |
| المصدر: | Journal of Ophthalmology. 2017:1-8 |
| بيانات النشر: | Hindawi Limited, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Intraocular pressure, business.industry, medicine.drug_class, Fixed-dose combination, Timolol, Ocular hypertension, medicine.disease, 030226 pharmacology & pharmacy, Confidence interval, 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, Tolerability, Anesthesia, 030221 ophthalmology & optometry, medicine, Travoprost, business, Beta blocker, medicine.drug |
| الوصف: | Objective. To evaluate the efficacy and tolerability of travoprost 0.004%/timolol 0.5% fixed-dose combination (TTFC) in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT) inadequately controlled on beta-blocker monotherapy.Methods. In this phase IV, open-label study, 156 patients on beta-blocker monotherapy with mean intraocular pressure (IOP) between 18 and 32 mmHg were randomized (no washout period) to receive TTFC for 8 weeks (TTFC group) or to continue beta-blocker monotherapy for 4 weeks followed by TTFC for the remaining 4 weeks (beta-blocker group).Results. The mean IOP (±standard deviation) at baseline in the TTFC and beta-blocker groups was22.5±2.5 mmHg and22.2±2.3 mmHg, respectively, and at weeks 4 and 8, was16.7±3.1 mmHg and16.1±3.1 mmHg, respectively, in TTFC group and21.1±3.1 mmHg and16.1±2.8 mmHg, respectively, in the beta-blocker group. There was a significant least squares mean difference between TTFC and beta-blocker in 8 a.m. IOP at week 4 (−4.6 mmHg; one-sided 95% confidence interval [−inf, −3.9];p<0.0001[primary endpoint]); the upper bound of the 95% confidence interval was within the prespecified limit (Conclusion. Superior IOP control was achieved with TTFC in patients with OAG or OHT previously uncontrolled with beta-blockers. No new safety findings were identified. This trial is registered with ClinicalTrials.govNCT02003391. |
| تدمد: | 2090-0058 2090-004X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::4374518460aafb86ce1b0141c78f2821 https://doi.org/10.1155/2017/1917570 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........4374518460aafb86ce1b0141c78f2821 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20900058 2090004X |
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