Synthesis and Anticonvulsant activity of new 5-((1-(2-(4-substituted phenacyl bromide)-2-oxoethyl)-2-phenyl-1H-indol-3yl) methylene) pyrimidine-2, 4, 6(1H, 3H, 5H)-trione Derivatives
| العنوان: | Synthesis and Anticonvulsant activity of new 5-((1-(2-(4-substituted phenacyl bromide)-2-oxoethyl)-2-phenyl-1H-indol-3yl) methylene) pyrimidine-2, 4, 6(1H, 3H, 5H)-trione Derivatives |
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| المؤلفون: | Bhumika Yogi, Sujeet Kumar Gupta, Surendra K Gautam |
| المصدر: | Research Journal of Pharmacy and Technology. :2681-2685 |
| بيانات النشر: | A and V Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Indole test, Pyrimidine, medicine.medical_treatment, Phenacyl bromide, 2-phenylindole-3-carbaldehyde, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences, Phenytoin Sodium, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Anticonvulsant, chemistry, medicine, N dimethylformamide, Pharmacology (medical), Methylene, Pharmacology, Toxicology and Pharmaceutics (miscellaneous) |
| الوصف: | In the current scenario we have plant to study to synthesize novel indole derivatives (4a-d) and (5a-b) which have the target activity like anti-convulsion and anti microbial etc. In the primary phase, we synthesized 2-phenyl-1H-indole reacted with Phosphorus oxychloride and N, N’-dimethylformamide by using vilsmeier reagent formylation of a new compound 2-phenylindole-3-carbaldehyde (2). The 2-phenylindole-3-carbaldehyde was reacted with substituted phenacyl bromide, K2CO3 and TBAB (Tetra butyl ammonium bromide) into the presence of N, N’-dimethylformamide to gives [1-(2-(4-substituted phenacyl bromide)-2-oxoethyl)-2-phenylindole-3-carbaldehyde (3a-d). The compound [1-(2-(4- substituted phenacyl bromide)-2-oxo-ethyl)-2-phenylindole-3-carbaldehyde was permitted to mixed with various substituted phenacyl bromide gives corresponding indole derivatives. The indole derivatives (3a-d) were reacted with barbituric acid and thiobarbituric acid dissolved into the methanol at reflux for 4h to gives afforded compounds (4a-d) and (5a-b). The final indole barbituric derivatives (4a-d) and (5a-b) were synthesized from substituted phenacyl bromide by the react with methanol and recrystalized from ethanol. The last compound has been completed on the basis of spectra FT-IR and 1H NMR. All the value of FT-IR, 1H NMR, Solubility and TLC were considered to be prominent. The pharmacological screening through ear electrode induced current 50mA for 0.2 seconds in electro-convulsiometer for anticonvulsant activity. The synthesize compounds were establish to be 4b, 4c, 4d, and 5a. The compound 4c and 5a were established to be the most potent compound through compare to standard drugs phenytoin sodium. |
| تدمد: | 0974-360X 0974-3618 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::45a56f37d6c02ebe7a3291ee7fc6af9c https://doi.org/10.52711/0974-360x.2021.00473 |
| رقم الأكسشن: | edsair.doi...........45a56f37d6c02ebe7a3291ee7fc6af9c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0974360X 09743618 |
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