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Investigation of DPYD, MTHFR and TYMS polymorphisms on 5-fluorouracil related toxicities in colorectal cancer

التفاصيل البيبلوغرافية
العنوان: Investigation of DPYD, MTHFR and TYMS polymorphisms on 5-fluorouracil related toxicities in colorectal cancer
المؤلفون: Mehtap Cevik, Esat Namal, Nur Dinc Sener, Ulkuhan Iner Koksal, Penbe Cagatay, Gokce Deliorman, Cavlan Ciftci, Atila Karaalp, Belgin Susleyici
المصدر: Personalized Medicine. 19:435-444
بيانات النشر: Future Medicine Ltd, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Pharmacology, Molecular Medicine, General Medicine
الوصف: Aim: To investigate the association of DPYD, MTHFR and TYMS polymorphisms on 5-fluorouracil (5-FU) related toxicities and patient survival. Materials & methods: A total of 103 colorectal cancer patients prescribed 5-FU were included in the study. Genotyping was conducted for several DPYD, MTHFR and TYMS polymorphisms using a microarray analyzer. Results: DPYD 496A>G polymorphism was found to be significantly associated with 5-FU related grade 0–2, but not severe toxicities (p = 0.02). Furthermore, patients with DPYD 85TC and CC genotypes had longer progression and overall survival times compared to TT genotypes in our study group (log rank = 6.60; p = 0.01 and log rank = 4.40; p = 0.04, respectively). Conclusion: According to our results, DPYD 496AG and GG genotypes might be protective against severe adverse events compared to the AA genotype. Another DPYD polymorphism, 85T>C, may be useful in colorectal cancer prognosis. Further studies for both polymorphisms should be conducted in larger populations to achieve accurate results.
تدمد: 1744-828X
1741-0541
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::45f02f77b9ba291e55ce91365a463d84
https://doi.org/10.2217/pme-2021-0047
رقم الأكسشن: edsair.doi...........45f02f77b9ba291e55ce91365a463d84
قاعدة البيانات: OpenAIRE
الوصف
تدمد:1744828X
17410541