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Ion mobility spectrometry of talarozole, a new azole drug, in cleaning quality control

التفاصيل البيبلوغرافية
العنوان: Ion mobility spectrometry of talarozole, a new azole drug, in cleaning quality control
المؤلفون: Céline Thierens, Bart De Spiegeleer, Bram Baert, Jente Boonen
المصدر: International Journal for Ion Mobility Spectrometry. 14:109-116
بيانات النشر: Springer Science and Business Media LLC, 2011.
سنة النشر: 2011
مصطلحات موضوعية: chemistry.chemical_classification, Detection limit, Talarozole, chemistry.chemical_compound, Chromatography, chemistry, Ion-mobility spectrometry, Analytical technique, Azole, Fractional factorial design, Cleaning validation, Quantitative analysis (chemistry), Spectroscopy
الوصف: Ion mobility spectrometry (IMS) gains increased pharmaceutical interest as an analytical technique for the verification of equipment cleaning. Using a fractional factorial design, we developed an IMS method for talarozole, which represents a new generation of retinoic acid metabolism blocking agents (RAMBA) that can be used for the treatment of different dermatological diseases, such as psoriasis and acne. Using a Smiths Detection Ionscan-LS and the optimal IMS settings obtained, talarozole showed a drift time of 16.648 ms, corresponding to a reduced ion mobility K0 of 1.072 cm²V−1s−1. Total analysis times below 1 min were achieved. Talarozole was well separated in the plasmagram from other azole compounds and the limit of detection was found to be 43 ng/ml. Swab samples collected from steel and glass plates were successfully analyzed, thereby showing that IMS is indeed a suitable technique for the quantitative analysis of talarozole in cleaning quality control.
تدمد: 1865-4584
1435-6163
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4621747e4c959cb9b6c244a89032c7ff
https://doi.org/10.1007/s12127-011-0063-z
حقوق: CLOSED
رقم الأكسشن: edsair.doi...........4621747e4c959cb9b6c244a89032c7ff
قاعدة البيانات: OpenAIRE
الوصف
تدمد:18654584
14356163