Characterization ofProphet of Pit-1Gene Expression in Normal Pituitary and Pituitary Adenomas in Humans1
| العنوان: | Characterization ofProphet of Pit-1Gene Expression in Normal Pituitary and Pituitary Adenomas in Humans1 |
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| المؤلفون: | Hiroyuki Murabe, Seiji Muro, Haruo Mizuta, Akira Shimatsu, Michio Suda, Kazuwa Nakao, Takeshi Usui, Kiyoshi Tanaka, Issei Tanaka, Yoshio Nakamura |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 84:1414-1419 |
| بيانات النشر: | The Endocrine Society, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Messenger RNA, medicine.medical_specialty, Pituitary gland, Adenoma, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, Biology, medicine.disease, Biochemistry, Molecular biology, humanities, Endocrinology, medicine.anatomical_structure, stomatognathic system, Complementary DNA, Internal medicine, Gene expression, medicine, Enhancer, Gene, Peptide sequence |
| الوصف: | Prophet of Pit-1 (Prop-1), which is a paired-like homeodomain transcription factor, is capable of binding to sites in an early enhancer of the Pit-1 gene and regulating its expression. According to a previous report, Prop-1 messenger RNA (mRNA) is expressed in the developing pituitary gland before Pit-1 mRNA expression and maximum expression are observed at e 12.0. After e 14.5, Prop-1 mRNA expression rapidly decreases, and only trace amounts of mRNA are detectable in adult mouse pituitary. Human Pit-1 is expressed considerably, not only in normal adult pituitary but also in pituitary adenomas, so we studied human Prop-1 gene expression in adult pituitary and pituitary adenomas. We also cloned human Prop-1 complementary DNA (cDNA) and sequenced the Prop-1 cDNAs in pituitary adenomas. The amino acid sequence of human Prop-1 cDNA that we cloned was identical to that of the previously reported sequence, except Thr substituted at codon 142 instead of Ala. This amino acid substitution is considered to be a pol... |
| تدمد: | 1945-7197 0021-972X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::46525a4627999d8222fbba2141615380 https://doi.org/10.1210/jcem.84.4.5630 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........46525a4627999d8222fbba2141615380 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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