Pharmacokinetics of cancer therapeutics and energy balance: the role of diet intake, energy expenditure, and body composition
| العنوان: | Pharmacokinetics of cancer therapeutics and energy balance: the role of diet intake, energy expenditure, and body composition |
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| المؤلفون: | Sarah A Purcell, Dieuwertje E Kok, Tyler Ketterl, Miriam B Garcia, Lenat Joffe, Justin C Brown, Christina M Dieli-Conwright, Grant R Williams |
| المصدر: | JNCI Monographs. 2023:3-11 |
| بيانات النشر: | Oxford University Press (OUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Cancer Research, Oncology |
| الوصف: | Energy balance accounts for an individual’s energy intake, expenditure, and storage. Each aspect of energy balance has implications for the pharmacokinetics of cancer treatments and may impact an individual’s drug exposure and subsequently its tolerance and efficacy. However, the integrated effects of diet, physical activity, and body composition on drug absorption, metabolism, distribution, and excretion are not yet fully understood. This review examines the existing literature on energy balance, specifically the role of dietary intake and nutritional status, physical activity and energy expenditure, and body composition on the pharmacokinetics of cancer therapeutics. As energy balance and pharmacokinetic factors can be influenced by age-related states of metabolism and comorbidities, this review also explores the age-related impact of body composition and physiologic changes on pharmacokinetics among pediatric and older adult populations with cancer. |
| تدمد: | 1745-6614 1052-6773 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::472601902770298a25ce67f858e7955a https://doi.org/10.1093/jncimonographs/lgad010 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........472601902770298a25ce67f858e7955a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17456614 10526773 |
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