Beneficial Effects of Cynaroside on Cisplatin-Induced Kidney InjuryIn VitroandIn Vivo
| العنوان: | Beneficial Effects of Cynaroside on Cisplatin-Induced Kidney InjuryIn VitroandIn Vivo |
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| المؤلفون: | Mi-Ok Sim, Ho-Kyung Jung, Mu-Jin Lee, Hyun-Woo Cho, Jong-Hyun Nho, Ji-Hun Jang, Da-Eun Jeong, Jong-Choon Kim |
| المصدر: | Toxicological Research. 34:133-141 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Cisplatin, business.industry, Health, Toxicology and Mutagenesis, Cynaroside, Pharmacology, Toxicology, medicine.disease, Nephrotoxicity, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Ototoxicity, chemistry, Apoptosis, In vivo, 030220 oncology & carcinogenesis, Toxicity, Medicine, Doxorubicin, business, medicine.drug |
| الوصف: | Anti-cancer drugs such as cisplatin and doxorubicin are effectively used more than radiotherapy. Cisplatin is a chemotherapeutic drug, used for treatment of various forms of cancer. However, it has side effects such as ototoxicity and nephrotoxicity. Cisplatin-induced nephrotoxicity increases tubular damage and renal dysfunction. Consequently, we investigated the beneficial effect of cynaroside on cisplatin-induced kidney injury using HK-2 cell (human proximal tubule cell line) and an animal model. Results indicated that 10 µM cynaroside diminished cisplatin-induced apoptosis, mitochondrial dysfunction and caspase-3 activation, cisplatin-induced upregulation of caspase-3/MST-1 pathway decreased by treatment of cynaroside in HK-2 cells. To confirm the effect of cynaroside on cisplatin-induced kidney injury in vivo, we used cisplatin exposure animal model (20 mg/kg, balb/c mice, i.p., once a day for 3 days). Renal dysfunction, tubular damage and neutrophilia induced by cisplatin injection were decreased by cynaroside (10 mg/kg, i.p., once a day for 3 days). Results indicated that cynaroside decreased cisplatin-induced kidney injury in vitro and in vivo, and it could be used for improving cisplatin-induced side effects. However, further experiments are required regarding toxicity by high dose cynaroside and caspase-3/ MST-1-linked signal transduction in the animal model. |
| تدمد: | 2234-2753 1976-8257 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::47452575ab96147f0ad412f638c7a8fb https://doi.org/10.5487/tr.2018.34.2.133 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........47452575ab96147f0ad412f638c7a8fb |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 22342753 19768257 |
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