Incidence and risk of antiresorptive agent-related osteonecrosis of the jaw (ARONJ) after tooth extraction in patients with autoimmune disease
| العنوان: | Incidence and risk of antiresorptive agent-related osteonecrosis of the jaw (ARONJ) after tooth extraction in patients with autoimmune disease |
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| المؤلفون: | Yuichiro Fujieda, Mototsugu Doi, Ryo Hisada, Hiraku Kameda, Daigo Nakazawa, Yoshimasa Kitagawa, Olga Amengual, Tatsuya Atsumi, Takuya Asaka, Naoki Ohnishi, Masaru Kato, Masahiko Takahata, Masahiro Ota, Michihiro Kono, Shinsuke Yasuda |
| المصدر: | Journal of Bone and Mineral Metabolism. 38:581-588 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Population, 030209 endocrinology & metabolism, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Medicine, Orthopedics and Sports Medicine, education, education.field_of_study, business.industry, Incidence (epidemiology), General Medicine, Perioperative, medicine.disease, Discontinuation, Dental extraction, Population study, 030101 anatomy & morphology, business, Complication, Osteonecrosis of the jaw |
| الوصف: | Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) is a rare but serious complication in patients receiving antiresorprtive agents (AR). However, the incidence of ARONJ after tooth extraction in patients with autoimmune disease (AID) remains unclear. The present study aimed to clarify the high-risk population of ARONJ in patients with AID. The study population comprised 232 patients treated with AR, AID or non-AID, who had undergone dental extraction from January 2011 to September 2017. The incidence and risk factors of ARONJ were analysed retrospectively. Additionally, the relationship between ARONJ and osteoporotic fracture (OF) and AR discontinuation during dental procedures was investigated. Of 232 patients, 10 developed ARONJ within 1 year of dental extraction. The incidence of ARONJ in patients with AID was higher than that in non-AID patients (2.0/100 person-year vs 0.5/100 person-year; p = 0.03). Among the AID patients, RA patients had strikingly high incidence of ARONJ (3.6/100 person-year). The incidence of neither ARONJ nor OF significantly differed between patients who continued and discontinued AR in the perioperative period. Patients with AID who undergo dental extraction are at high risk of ARONJ. Discontinuation of AR would not significantly contribute to reduce the incidence of ARONJ in those patients. |
| تدمد: | 1435-5604 0914-8779 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::47aa09acdb12d0ec688882b4dea1f6d4 https://doi.org/10.1007/s00774-020-01089-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........47aa09acdb12d0ec688882b4dea1f6d4 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14355604 09148779 |
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