13C-Acetat-Atemtest zur nicht-invasiven Beurteilung der Magenentleerung einer flüssig-festen Testmahlzeit bei Diabetikern
| العنوان: | 13C-Acetat-Atemtest zur nicht-invasiven Beurteilung der Magenentleerung einer flüssig-festen Testmahlzeit bei Diabetikern |
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| المؤلفون: | Pfaffenbach B, Y. H. Lee, Romuald J. Adamek, Schaffstein J, M. Wegener |
| المصدر: | DMW - Deutsche Medizinische Wochenschrift. 121:713-718 |
| بيانات النشر: | Georg Thieme Verlag KG, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Breath test, medicine.medical_specialty, Percentile, Reproducibility, medicine.diagnostic_test, Gastric emptying, business.industry, digestive, oral, and skin physiology, chemistry.chemical_element, General Medicine, Scintigraphy, medicine.disease, Technetium, Gastroenterology, chemistry, Internal medicine, medicine, Gastroparesis, business, Prospective cohort study |
| الوصف: | OBJECTIVE To test in a prospective study whether the non-invasive 13C-acetate test is suitable for measuring gastric emptying time with a liquid/solid test meal. (99m)technetium scintigraphy served as the reference method. PATIENTS AND METHODS 18 consecutive type 2 diabetics with symptoms of gastroparesis (nine men, nine women; mean age 64 [45-76] years) were, after a nocturnal fasting period, given a liquid/solid test meal (370 kcal; 100 ml coffee; doubly marked with 75 mg 13C-acetate and 0.5 mCi 99mTc-colloid). At ten-minute intervals breath samples were taken over two hours and examined by mass spectometry for the 13CO2/12CO2 ratio. In parallel scintigraphy was performed for one hour at one-minute intervals. Gastric emptying half-life (t1/2) was calculated and the correlation between the two methods determined. In addition, the 13C-acetate breath test was performed on 20 healthy subjects to assess reproducibility (ten men, ten women; mean age 44.4 [23-77] years). RESULTS Median t1/2 with the scintigraphy was 93.5 min, with the breath test 55 min, i.e. a significant correlation (r = 0.8; P < 0.001). Four of five patients with delayed gastric emptying by scintigraphy also showed delay (compared with the control group) in the breath test (median t1/2: 41 min; 95th percentile: 86 min). CONCLUSION The 13C-acetate test correlated significantly with the results by scintigraphy. It can therefore be recommended as a non-invasive test for assessing gastric emptying time after a liquid/solid test meal in type 2 diabetics. |
| تدمد: | 1439-4413 0012-0472 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::47f9811d1a34a1383a0545d833efa9fb https://doi.org/10.1055/s-2008-1043059 |
| رقم الأكسشن: | edsair.doi...........47f9811d1a34a1383a0545d833efa9fb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14394413 00120472 |
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