Die prognostische Bedeutung der immunhistochemisch ermittelten Kathepsin D-Synthese beim Endometriumkarzinom
| العنوان: | Die prognostische Bedeutung der immunhistochemisch ermittelten Kathepsin D-Synthese beim Endometriumkarzinom |
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| المؤلفون: | H. Caffier, S. Krebs, Jael Backe, A. M. Gassel |
| المصدر: | Geburtshilfe und Frauenheilkunde. 57:429-434 |
| بيانات النشر: | Georg Thieme Verlag KG, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Gynecology, medicine.medical_specialty, business.industry, Endometrial cancer, Obstetrics and Gynecology, medicine.disease, Endometrium, Gastroenterology, Log-rank test, medicine.anatomical_structure, Internal medicine, Maternity and Midwifery, Progesterone receptor, Carcinoma, Medicine, Immunohistochemistry, business, Receptor, Grading (tumors) |
| الوصف: | The production of Kathepsin D was detected immunohistochemically in a retrospective analysis of 225 endometrial carcinomas and correlated to survival of patients. Median follow-up period was 5.4 years. Overproduction of Kathepsin D could be found in 105 (53%) of 225 tumors. Univariate regression analysis revealed no significant influence of Kathepsin D production on adjusted survival (log rank p = 0,14) and on disease-free survival (p = 0.34) of patients. There was no correlation of Kathepsin D with age of patients (p=0.07), myometrial invasion (p=0.71), histologic grading (p=0.96) and with immunohistochemically detected parameters estradiol receptor (p=0.34), progesterone receptor (p=0.31) and growth fraction (p=0.23), as detected by the monoclonal antibody Ki-S1.In multivariate analysis Kathepsin D overproduction could not be established as independent prognosticator of adjusted survival (p=0.37) and disease-free survival (p=0.63) as compared to independent predictors FIGO-stage, histologic grading and growth fraction of endometrial carcinoma. In conclusion, Kathepsin D production, according to the results of the long-term follow-up-study, cannot be confirmed as prognosticator in endometrial cancer. |
| تدمد: | 1438-8804 0016-5751 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::494dbd554239307563d5ca2b3d7e355b https://doi.org/10.1055/s-2007-1023112 |
| رقم الأكسشن: | edsair.doi...........494dbd554239307563d5ca2b3d7e355b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14388804 00165751 |
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