Complementary roles of differential medial entorhinal cortex inputs to the hippocampus for the formation and integration of temporal and contextual memory (Systems Neuroscience)
العنوان: | Complementary roles of differential medial entorhinal cortex inputs to the hippocampus for the formation and integration of temporal and contextual memory (Systems Neuroscience) |
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المؤلفون: | Takashi Kitamura, Naoki Yamamoto, William D. Marks |
المصدر: | European Journal of Neuroscience. 54:6762-6779 |
بيانات النشر: | Wiley, 2020. |
سنة النشر: | 2020 |
مصطلحات موضوعية: | Systems neuroscience, 0303 health sciences, Recall, Computer science, General Neuroscience, Hippocampus, Context (language use), Tracing, 03 medical and health sciences, 0302 clinical medicine, Encoding (memory), Biological neural network, Spatial analysis, Neuroscience, 030217 neurology & neurosurgery, 030304 developmental biology |
الوصف: | In humans and rodents, the entorhinal cortical (EC)-hippocampal (HPC) circuit is crucial for the formation and recall of memory, preserving both spatial information and temporal information about the occurrence of past events. Both modeling and experimental studies have revealed circuits within this network that play crucial roles in encoding space and context. However, our understanding about the time-related aspects of memory is just beginning to be understood. In this review, we first describe updates regarding recent anatomical discoveries for the EC-HPC network, as several important neural circuits critical for memory formation have been discovered by newly developed neural tracing technologies. Second, we examine the complementary roles of multiple medial entorhinal cortical inputs, including newly discovered circuits, into the hippocampus for the temporal and spatial aspects of memory. Finally, we will discuss how temporal and contextual memory information is integrated in HPC cornu ammonis 1 cells. We provide new insights into the neural circuit mechanisms for anatomical and functional segregation and integration of the temporal and spatial aspects of memory encoding in the EC-HPC networks. |
تدمد: | 1460-9568 0953-816X |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::4a21144a9ca2be474cf47dba10a69974 https://doi.org/10.1111/ejn.14737 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi...........4a21144a9ca2be474cf47dba10a69974 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 14609568 0953816X |
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