Antitumor Activity of Vanicoside B Isolated from Persicaria dissitiflora by Targeting CDK8 in Triple-Negative Breast Cancer Cells
| العنوان: | Antitumor Activity of Vanicoside B Isolated from Persicaria dissitiflora by Targeting CDK8 in Triple-Negative Breast Cancer Cells |
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| المؤلفون: | Thi-Thu-Trang Luu, Ruoci Hu, Donghwa Kim, Sang Kook Lee, Cai Yi Wang, Ji Yun Lee, Hee-Juhn Park |
| المصدر: | Journal of Natural Products. 82:3140-3149 |
| بيانات النشر: | American Chemical Society (ACS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Pharmacology, Cell cycle checkpoint, biology, Chemistry, Kinase, Organic Chemistry, Pharmaceutical Science, biology.organism_classification, medicine.disease, Analytical Chemistry, Nude mouse, Breast cancer, Complementary and alternative medicine, Downregulation and upregulation, Cell culture, Apoptosis, Drug Discovery, Cancer research, medicine, Molecular Medicine, Triple-negative breast cancer |
| الوصف: | A flavonoid glycoside, quercitrin (1), and two phenylpropanoyl sucrose derivatives, vanicoside B (2) and lapathoside C (3), were isolated for the first time from the herb Persicaria dissitiflora. Vanicoside B (2) exhibited antiproliferative activity against a panel of cancer cell lines in triple-negative breast cancer (TNBC) MDA-MB-231 cells. The underlying mechanisms of the antitumor activity of 2 were investigated in TNBC cells. Upregulation of cyclin-dependent kinase 8 (CDK8) was observed in a claudin-low molecular subtype of TNBC cells. A molecular modeling study indicated that 2 showed a high affinity for CDK8. Further investigations revealed that 2 suppressed CDK8-mediated signaling pathways and the expression of epithelial-mesenchymal transition proteins and induced cell cycle arrest and apoptosis in MDA-MB-231 and HCC38 TNBC cells. Moreover, 2 inhibited tumor growth without overt toxicity in a nude mouse xenograft model implanted with MDA-MB-231 cells. Taken together, these findings demonstrate the significance of CDK8 activity in TNBC and suggest a potential use of 2 as a therapeutic candidate for the treatment of aggressive human triple-negative breast cancer. |
| تدمد: | 1520-6025 0163-3864 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::4aee220c4db6b94bfc6271ef68d00a31 https://doi.org/10.1021/acs.jnatprod.9b00720 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........4aee220c4db6b94bfc6271ef68d00a31 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15206025 01633864 |
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