A Diversified Assembly of 1,2,4-Oxadiazol-3-amines: Metallic Thiophile Catalyzed Chemoselective One-Pot Reaction of Aryl Isothiocyanates, Amidines/Guanidines, and Hydroxylamine
| العنوان: | A Diversified Assembly of 1,2,4-Oxadiazol-3-amines: Metallic Thiophile Catalyzed Chemoselective One-Pot Reaction of Aryl Isothiocyanates, Amidines/Guanidines, and Hydroxylamine |
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| المؤلفون: | V. Sudarsanam, Hitesh B. Jalani, Kamala K. Vasu |
| المصدر: | Synthesis. 44:3378-3386 |
| بيانات النشر: | Georg Thieme Verlag KG, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Aryl, Organic Chemistry, Combinatorial chemistry, Catalysis, Flue-gas desulfurization, Metal, chemistry.chemical_compound, Hydroxylamine, chemistry, Intramolecular force, One pot reaction, visual_art, visual_art.visual_art_medium, Chemoselectivity |
| الوصف: | An efficient one-pot synthesis of 1,2,4-oxadiazol-3-amines from simple starting materials, isothiocyanates, amidines/guanidines, and hydroxylamine, is described. The reaction is facilitated by metallic-thiophile-assisted desulfurization of in situ formed amidino- or guanidinothiourea to give chemoselectively N -hydroxyguanidine intermediates that give exclusively various 1,2,4-oxadiazol-3-amines in good to excellent yields. The reaction mechanistic pathway may proceed through an intramolecular 5 - exo - trig cyclization. |
| تدمد: | 1437-210X 0039-7881 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::4c15a0b9b91eb96a8deacb1bac463053 https://doi.org/10.1055/s-0032-1317504 |
| رقم الأكسشن: | edsair.doi...........4c15a0b9b91eb96a8deacb1bac463053 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1437210X 00397881 |
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