The numerical simulation of cavitation flow field in a Francis turbine runner with attached blades was conducted based on the no-slip mixture model in the Euler approach and the Singhal cavitation model. The RNG model after correcting viscosity and the pressure correction algorithm (SIMPLE) were supplemented. The distributions of the water-vapor volume fraction under non-design conditions were obtained. The results show that the method based on two-phase mixture model can be used to simulate the position and degree of cavitation flow in Francis turbine.