0087 Long-term day-and-night rotating shift work poses a barrier against the normalisation of liver function
| العنوان: | 0087 Long-term day-and-night rotating shift work poses a barrier against the normalisation of liver function |
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| المؤلفون: | Yu-Cheng Lin, I-Chun Hsieh, Pau-Chung Chen |
| المصدر: | Occupational and Environmental Medicine. 71:A72.1-A72 |
| بيانات النشر: | BMJ, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, biology, business.industry, Confounding, Public Health, Environmental and Occupational Health, Mean age, Logistic regression, Surgery, Male workers, Rotating Shift Work, Alanine transaminase, Cohort, biology.protein, Medicine, Liver function, business, Demography |
| الوصف: | Objectives To evaluate the impact of day-and-night rotating shift work (RSW) on liver health, we analysed the association between long term RSW exposure and the normalisation of plasma alanine transaminase (ALT) levels over a five-year period. Method The data from physical examinations, blood tests, abdominal sonographic examinations, personal histories, and occupational records were collected from a cohort of workers in a semiconductor manufacturing company. The sample population was divided into three subgroups for analysis: persistent daytime workers, workers exposed intermittently to RSW (i-RSW), and exposed to persistent RSW (p-RSW). Results Records were analysed for 1196 male workers with an initial mean age of 32.5 years (SD 6.0 years), of whom 821 were identified as rotating shift workers, including 374 i-RSW and 447 p-RSW workers. At the beginning of the follow-up, 275 were found to have elevated ALT (e-ALT): 25.1% day-time workers, 23.0% i-RSW workers and 21.3% p-RSW workers. Of those with e-ALT at the beginning, 101 workers showed normalised serum ALT levels at the end of five-year follow-up: 10.7% of day-time workers, 8.6% of i-RSW workers, and 6.5% of p-RSW workers; P = 0.016). By performing multivariate logistic regression analyses, and comparing with the persistent daytime co-workers, after controlling for confounding variables, analysis indicated that the workers exposed to p-RSW were 46% less likely (OR, 0.54; 95% CI, 0.30–0.95; P = 0.03) to attain normal ALT levels within a five-year interval. Conclusions Persistent day-and-night RSW pose a vigorous obstacle to the normalisation of e-ALT among workers with preexing abnormal liver function. |
| تدمد: | 1470-7926 1351-0711 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::51005ce4721cf597e77b5de2d936ffab https://doi.org/10.1136/oemed-2014-102362.223 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........51005ce4721cf597e77b5de2d936ffab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14707926 13510711 |
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