Effects of Stress Hyperglycemia on Acute Myocardial Infarction
| العنوان: | Effects of Stress Hyperglycemia on Acute Myocardial Infarction |
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| المؤلفون: | Umberto De Fanis, Federico Cacciapuoti, Riccardo Giunta, Mario Verza, Michele Portoghese, Ausilia Sellitto, Raffaele Marfella, Dario Giugliano, Silvio Siciliano, Francesco Nappo, Ferdinando Carlo Sasso, Giacomo Lucivero, Nicola Mininni, Mario Siniscalchi, Ciro Romano, Katherine Esposito |
| المصدر: | Diabetes Care. 26:3129-3135 |
| بيانات النشر: | American Diabetes Association, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Advanced and Specialized Nursing, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Inflammation, Stress hyperglycemia, medicine.disease, Endocrinology, Immune system, Antigen, Internal medicine, Diabetes mellitus, Internal Medicine, Cardiology, medicine, Myocardial infarction complications, Myocardial infarction, medicine.symptom, business, CD8 |
| الوصف: | OBJECTIVE—Stress hyperglycemia has been associated with increased mortality in patients with myocardial infarction (MI). We examined the association between plasma glucose levels, circulating inflammatory markers, T-cell activation, and functional cardiac outcome in patients with first MI. RESEARCH DESIGN AND METHODS—Echocardiographic parameters, circulating levels of interleukin-18 (IL-18), C-reactive protein (CPR), and the percent of CD16-CD56, CD4/CD8, CD152, and HLA-DR expression were investigated in 108 patients with acute MI on admission to the emergency ward. RESULTS—Our review found that 31 new hyperglycemic patients (glycemia ≥7 mmol/l) had higher infarct segment length (P < 0.05) and myocardial performance index (P < 0.02) and reduced transmitral Doppler flow (P < 0.05), pulmonary flow analysis (P < 0.02), and ejection fraction (P < 0.05) compared with 36 hyperglycemic diabetic patients and 41 normoglycemic patients. Plasma IL-18 and CRP were higher in the hyperglycemic than in the normoglycemic patients (P < 0.005), with the highest values in patients with new hyperglycemia (P < 0.05). Hyperglycemic patients had a higher percent of CD16+/CD56+ cells and CD4/CD8 ratio (P < 0.01), whereas they had lower CD152 expression (which has a negative regulatory function in T-cell activation) compared with normoglycemic patients (P < 0.001). CONCLUSIONS—During MI, hyperglycemia is associated with increased levels of inflammatory markers, enhanced expression of cytotoxic T-cells, and reduced expression of T-cells, which are implicated in limiting the immune process. An increased inflammatory immune process seems a likely mechanism linking acute hyperglycemia to poor cardiac outcome in MI patients. |
| تدمد: | 1935-5548 0149-5992 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::513fa8bbc91082d9f31087eb617149e0 https://doi.org/10.2337/diacare.26.11.3129 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........513fa8bbc91082d9f31087eb617149e0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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