Supplementation of Taurine Insulates Against Oxidative Stress, Confers Neuroprotection and Attenuates Memory Impairment in Noise Stress Exposed Male Wistar Rats
| العنوان: | Supplementation of Taurine Insulates Against Oxidative Stress, Confers Neuroprotection and Attenuates Memory Impairment in Noise Stress Exposed Male Wistar Rats |
|---|---|
| المؤلفون: | Syeda Madiha, Zehra Batool, Laraib Liaquat, Noor Kamil, Irfan Sajid, Saiqa Tabassum, Saara Ahmad, Saima Khaliq, Sadia Sadir, Saida Haider |
| المصدر: | Neurochemical Research. 45:2762-2774 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Taurine, Population, Morris water navigation task, Hippocampus, Biochemistry, Neuroprotection, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Neurochemical, Internal medicine, medicine, Memory impairment, Memory disorder, education, education.field_of_study, business.industry, General Medicine, medicine.disease, 030104 developmental biology, Endocrinology, chemistry, business, 030217 neurology & neurosurgery |
| الوصف: | Noise has always been an important environmental factor that induces health problems in the general population. Due to ever increasing noise pollution, humans are facing multiple auditory and non-auditory problems including neuropsychiatric disorders. In modern day life it is impossible to avoid noise due to the rapid industrialization of society. Continuous exposure to noise stress creates a disturbance in brain function which may lead to memory disorder. Therefore, it is necessary to find preventive measures to reduce the deleterious effects of noise exposure. Supplementation of taurine, a semi essential amino acid, is reported to alleviate psychiatric disorders. In this study noise-exposed (100 db; 3 h daily for 15 days) rats were supplemented with taurine at a dose of 100 mg/kg for 15 days. Spatial and recognition memory was assessed using the Morris water maze and novel object recognition task, respectively. Results of this study showed a reversal of noise-induced memory impairment in rats. The derangements of catecholaminergic and serotonergic levels in the hippocampus and altered brain antioxidant enzyme activity due to noise exposure were also restored by taurine administration. This study highlights the importance of taurine supplementation to mitigate noise-induced impaired memory via normalizing the neurochemical functions and reducing oxidative stress in rat brain. |
| تدمد: | 1573-6903 0364-3190 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::518efb19c5a2d15fa90e9092144dda4c https://doi.org/10.1007/s11064-020-03127-7 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........518efb19c5a2d15fa90e9092144dda4c |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15736903 03643190 |
|---|