Septic shock is frequently associated with relative adrenal insufficiency (RAI). RAI increases mortality and hydrocortisone supplementation improves survival in septic shock patients. There is no consensus about RAI diagnosis criteria. With the standard corticotropin stimulation test (SCST) (250 μg) ACTH levels reaches 100 times the physiological concentration. A low-dose corticotropin stimulation test (LDCST) (1 μg) is closer to physiological ACTH levels.