Purpose. To compare between the effects of balance-based torso weighting and tailored physical therapy program in improving balance and postural control in ataxic MS patients. Methods. Ninety patients diagnosed as multiple sclerosis with impaired balance and postural control were selected from outpatient clinic of two hospitals. The patients randomly assigned into two groups, group (A: n = 30) received torso-based balance weighting and group (B; n = 60) received tailored physical therapy program. Both groups received conventional physical therapy program for balance and postural control. Treatment lasted eight weeks, three times per week. Pre- and post-treatment assessment using berg balance scale and overall stability index were done for all patients. Results. The comparison between both groups post-treatment revealed statistically significant increase in Berg balance (p < 0.05) in favour of experimental group (B). Conclusion. Tailored physical therapy program has a significant effect on improving balance and postural control in ataxic MS patients.