Levetiracetam exposure during prenatal and postnatal period induces cognitive decline in rat offsprings, not completely prevented by Bacopa monnieri
| العنوان: | Levetiracetam exposure during prenatal and postnatal period induces cognitive decline in rat offsprings, not completely prevented by Bacopa monnieri |
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| المؤلفون: | Amrita Parida, Sudhishma, Vandana Blossom, Sahana D Acharya, Sheetal D Ullal, Nadira Noushida |
| المصدر: | Journal of Complementary and Integrative Medicine. 19:897-903 |
| بيانات النشر: | Walter de Gruyter GmbH, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, biology, Offspring, business.industry, Physiology, Morris water navigation task, biology.organism_classification, Bacopa, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Complementary and alternative medicine, Gum acacia, Hippocampus (mythology), Medicine, Bacopa monnieri, Levetiracetam, Cognitive decline, business, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Objectives Levetiracetam (LEV) is an antiepileptic recommended during pregnancy. Bacopa monneri is a medicinal herb used in Ayurveda for improvement of cognition. Data on effects of LEV and Bacopa on cognition is inadequate. The study evaluated the cognitive effects of LEV on rat offspring of dams exposed to LEV and whether pretreatment with Bacopa monnieri, inhibits the potential cognitive decline by LEV. Methods Pregnant rats were allocated into four groups of three rats each. Groups 1, 2, 3 and 4 received 2% gum acacia, LEV 270 mg/kg, LEV 270 mg/kg + Bacopa 100 mg/kg and LEV 270 mg/kg + Bacopa 200 mg/kg respectively during pregnancy and lactation. Three pups from all dams were chosen at random and exposed to passive avoidance, Hebb-Williams and Morris water maze tests to check for their cognition and relevant histopathology was done. Results In the passive avoidance model groups 3 and 4, showed an increase in escape latency compared with group 2, demonstrating an improved learning (p=0.05). In Hebb-Williams maze, the time taken to reach reward chamber by group 2 increased compared to group 1, p=0.006, showing cognitive decline. Neuronal count in hippocampus and prefrontal cortex decreased significantly in group 2, which improved in group 3 & 4 however there was distortion of architecture in group 4. Conclusions LEV exposure in intrauterine and neonatal period induced cognitive decline in rat offsprings and Bacopa 100 mg/kg prevented LEV induced cognitive decline. However safety of exposure to Bacopa during the gestation period has to be evaluated. |
| تدمد: | 1553-3840 2194-6329 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::548b042ee3d8870f84136f9d58111d92 https://doi.org/10.1515/jcim-2020-0424 |
| رقم الأكسشن: | edsair.doi...........548b042ee3d8870f84136f9d58111d92 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15533840 21946329 |
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