Early Life Imprinting of a Th2-Stromal Cell Niche in Skin
| العنوان: | Early Life Imprinting of a Th2-Stromal Cell Niche in Skin |
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| المؤلفون: | Ian C Boothby, Devi P Boda, Elaine Y Kwan, Jarish N Cohen, Ireneusz Habrylo, Ari B Molofsky, Michael D Rosenblum |
| المصدر: | The Journal of Immunology. 206:17.03-17.03 |
| بيانات النشر: | The American Association of Immunologists, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Tissue inflammation early in life can be imprinted on the immune system, causing lasting changes in immunologic tone that confer disease protection or susceptibility in adults. The cellular and molecular mechanisms responsible for immune imprinting in many nonlymphoid tissues remain largely unknown. We find that time-limited neonatal inflammation induced by transient reduction of regulatory T cells (Tregs) causes a dramatic dysregulation of skin stromal cells, accompanied by the selective accumulation of Th2 cells within a distinct microanatomic tissue niche. Th2 cells are maintained into adulthood through interactions with a previously uncharacterized stromal population in skin fascia that we refer to as Th2-interacting fascial fibroblasts (TIFFs), which expand following Treg reduction, respond to Th2 cytokines, and produce IL-33. Formation of the Th2-TIFF niche imprints skin with increased reparative capacity after wounding. Taken together, these data define a novel Th2 niche in skin and suggest a mechanism of immunologic imprinting whereby inflammation early in life creates networks between adaptive immune cells and parenchymal cells, establishing an immunological set-point in tissues that is maintained throughout life. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::54ec6788a838d6d76700f664e81a9f27 https://doi.org/10.4049/jimmunol.206.supp.17.03 |
| رقم الأكسشن: | edsair.doi...........54ec6788a838d6d76700f664e81a9f27 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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