West African savannas undergo severe changes due to climate change and land use pressure, resulting in degradation and biodiversity loss. These changes directly impact local rural livelihoods, as many cash poor rural communities depend on the provisioning ecosystem services of their environments. In a case study of the interdisciplinary research project UNDESERT, the increasingly challenging sustainable use of wild plant species in West African savannas was investigated. In this study, we present the results and give examples of how scientific results can serve for practical actions to foster sustainable use of important plant resources.