Synthesis and Stability of New Nitrophenol Complexes of 99m Tc as Possible Hypoxia Imaging Radiopharmaceuticals
| العنوان: | Synthesis and Stability of New Nitrophenol Complexes of 99m Tc as Possible Hypoxia Imaging Radiopharmaceuticals |
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| المؤلفون: | P. Kumar, M. Binehshmarvasti, L. I. Wiebe, A. R. Jalilian |
| المصدر: | Radiochemistry. 47:204-208 |
| بيانات النشر: | Springer Science and Business Media LLC, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Tumor imaging, Nitrophenol, chemistry.chemical_compound, Chromatography, chemistry, Chelation, Physical and Theoretical Chemistry, High-performance liquid chromatography, In vitro, Nuclear chemistry |
| الوصف: | Seven new nitrophenol derivatives were synthesized; their 99m Tc complexes (N2OS chelates), which are possible hypoxia tumor imaging agents, were prepared by the reaction with [99m Tc]NaTcO4 in the presence of SnCl2 at pH 10. The in vitro biostabilty of the complexes was evaluated. The purity and stability (in human and rat serum) of the complexes were evaluated by chromatographic methods (TLC, HPLC). The most stable (for more than 6 h) is the complex of 99m Tc with 3-[3′-N-(2″-hydroxy-5″-nitrobenzylamino)-2′-hydroxypropyl]-1-methylthiourea. |
| تدمد: | 1608-3288 1066-3622 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5674a9c7e2ca37e23caa616b0712dea1 https://doi.org/10.1007/s11137-005-0075-9 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........5674a9c7e2ca37e23caa616b0712dea1 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 16083288 10663622 |
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