24th Annual Meeting of the British Society of Toxicological Pathologists: Biomarkers of Safety and Pharmacology. Meeting Abstracts
| العنوان: | 24th Annual Meeting of the British Society of Toxicological Pathologists: Biomarkers of Safety and Pharmacology. Meeting Abstracts |
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| المؤلفون: | Calvert Louden, Frank Dieterle, William J. Reagan, Malcolm York, Dominique Brees, David Reynolds |
| المصدر: | Toxicologic Pathology. 38:203-206 |
| بيانات النشر: | SAGE Publications, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Circulatory collapse, Mechanism (biology), business.industry, medicine.medical_treatment, Organ dysfunction, Ischemia, Acute-phase protein, Cell Biology, Toxicology, medicine.disease, Bioinformatics, Pathology and Forensic Medicine, Proinflammatory cytokine, Systemic inflammatory response syndrome, Cytokine, medicine, medicine.symptom, business, Molecular Biology |
| الوصف: | Systemic inflammatory response syndrome (SIRS) is a ‘‘state of whole body inflammation’’ that can result in multiple organ dysfunction (MOD) circulatory collapse and even death. SIRS is considered as a self-defense mechanism to nonspecific insults that arise from chemical, necrotic (as a result of tissue damage), ischemic, or infectious stimuli that induce organ pathology. SIRS and MOD are complex processes that involve hemodynamic, humoral and cellular responses, complement activation, and cytokine cascade. SIRS and MOD develop in stages that are mediated in part through acute phase proteins, cytokine dysregulation, and hemodynamic events. In toxicology studies, safety evaluation of xenobiotics, pharmacologically active immune stimulants, and immunosuppressants can induce SIRS and MOD in rats, dogs, and nonhuman primates, and therefore, measurement of circulating mediators as biomarkers of SIRS and MOD will enable clinicians to avoid a potentially severe catastrophic event. Furthermore, chemically induced pathology resulting from events such as ischemia, extensive tissue damage and necrosis, and activation and release of stress hormones all can induce SIRS and MOD as a secondary toxic response. Whole-body SIRS is considered an adverse finding in preclinical toxicology studies. Therefore, knowledge and use of the appropriate inflammatory biomarkers that reflect this pathological process is quite useful both preclinically and clinically. Additionally, preclinical and clinical monitoring of biomarkers that are early predictors or reporters of SIRS are valuable to the toxicologist in hazard identification and risk assessment of novel therapeutics with the potential to cause a proinflammatory response. |
| تدمد: | 1533-1601 0192-6233 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::575f7bdf1a972d2e5260b521f1dccb46 https://doi.org/10.1177/0192623309356454 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........575f7bdf1a972d2e5260b521f1dccb46 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15331601 01926233 |
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